Advances in Fusion Gene Research and Fusion Gene Families in Hematological Malignancies
نویسندگان
چکیده
منابع مشابه
Association between Cytochrome P450 2C19 Gene Polymorphisms and Hematological Malignancies in an Iranian Population
Background: Cytochrome P450 2C19 (CYP2C19) is widely involved in the metabolism of some medications. On the other hand, recent studies have shown the contribution of the CYP2C19 polymorphisms to different malignancies. We aimed to investigate the association between CYP2C19 polymorphism and occurrence of hematological malignancies by comparing the phenotype distribution of this enzyme in patien...
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The mixed lineage leukemia (MLL) locus is involved in more than 60 different rearrangements with a remarkably diverse group of fusion partners in approximately 10% of human leukemias. MLL rearrangements include chromosomal translocations, gene internal duplications, chromosome 11q deletions or inversions and MLL gene insertions into other chromosomes, or vice versa. MLL fusion partners can be c...
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Background: The purpose of this study was to clone, express, and purify a novel multidomain fusion protein of Micobacterium tuberculosis (Mtb) in a prokaryotic system. Methods: An hspX/esxS gene construct was synthesized and ligated into a pGH plasmid, E. coli TOP10 cells were transformed, and the vector was purified. The vector containing the construct and pET-21b (+) plasmid were digested ...
متن کاملPerspective on Possible Recombination Event in Fusion Protein Gene of Newcastle Disease Viruses Isolated in Iran
Background and Aims: Newcastle disease (ND), caused by the virulent Newcastle disease virus (NDV), is one of the most important viral diseases in birds. In recent years recombination occurring throughout the NDVs genome isolated in China and Indonesia has been reported. This study was focused to investigate the recombination events in the F gene of the Iranian NDVs to generate useful data that ...
متن کاملCharacterization of Iranian Avian Metapneumovirus based on Fusion Gene (F)
Avian metapneumovirus (aMPV) represents one of the most prevalent diseases of poultry mainly in combination with other pathogens, and it is increasing among chickens. In the present study, the detection and characterization of an aMPV subtype B strain circulating in broiler flocks based on fusion (F) gene. In phylogenetic analysis, the isolates are located in B subtype cl...
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ژورنال
عنوان ژورنال: International Journal of Medical Reviews
سال: 2019
ISSN: 2345-525X
DOI: 10.29252/ijmr-060204